Which PRP is best for beauty? Platelet-Rich Plasma (PRP) has emerged as a major innovation in the aesthetic medicine field. Thanks to its natural origin, high safety, and short recovery time, PRP has rapidly become a preferred choice in non-surgical cosmetic treatments.
Whether for facial rejuvenation, skin texture improvement, under-eye correction, or hair restoration, PRP is widely used in aesthetic clinics around the world. As demand diversifies, so do the formulations of PRP — including ACD-A PRP, I-PRF, HA-enriched PRP, and Biotin PRP — each with unique properties and application value.
But which PRP is truly best for beauty? This article provides a comprehensive overview of PRP types, their composition, clinical effects, and recommended use cases.
What Is PRP and Why Is It Popular in Aesthetic Medicine?
The medical team derives Platelet-Rich Plasma (PRP) from the patient’s blood and prepares it using a controlled centrifugation process. The resulting plasma is rich in platelets and bioactive growth factors, including:
- PDGF (Platelet-Derived Growth Factor)
- TGF-β (Transforming Growth Factor Beta)
- VEGF (Vascular Endothelial Growth Factor)
- EGF (Epidermal Growth Factor)
These factors stimulate collagen regeneration, cell turnover, and tissue repair when injected into the skin, improving skin texture, tone, elasticity, and radiance.
As an autologous material, PRP eliminates the risk of immune rejection or cross-contamination. This treatment especially benefits patients with sensitive skin or those seeking a natural-looking rejuvenation effect. That’s why PRP has become a cornerstone of regenerative aesthetic therapies.
Common PRP Types in Aesthetics
1. ACD-A PRP
This formulation uses ACD-A (acid citrate dextrose solution A) as an anticoagulant. It helps preserve platelet viability and functionality during centrifugation.
Key advantages include:
- No pro-coagulant additives, making it ideal for combination treatments (e.g., microneedling, fillers)
- High biocompatibility and minimal irritation
- Suitable for first-time patients or general facial rejuvenation
ACD-A PRP is widely used for improving fine lines, restoring skin glow, and slowing the early signs of aging.
2. Sodium Citrate + Gel PRP
This formulation contains sodium citrate as an anticoagulant and a separation gel that enables clear stratification of the plasma and red blood cell layers.
Benefits include:
- Easy extraction of the platelet-rich layer
- More consistent concentration and purer composition
- Ideal for clinics aiming for standardized preparation protocols
It is commonly used in under-eye correction, pigmentation treatment, and general skin brightening.
3. Sodium Citrate + Gel + HA PRP
By adding hyaluronic acid (HA) to a gel-based PRP, this formulation enhances both regenerative and hydrating effects.
Recommended for:
- Dry or aging skin
- Areas prone to fine lines (e.g., eyes, lips)
- Patients seeking volume and moisture improvement
It’s a popular choice for facial anti-aging treatments where moisture retention and elasticity enhancement are key.
4. Sodium Citrate + Gel + Biotin PRP
Biotin (vitamin B7) is added to promote cellular metabolism and support follicle vitality.
Best suited for:
- Early-stage hair thinning
- Postpartum or stress-related hair loss
- Scalp conditions involving inflammation or poor circulation
This formulation is widely used in hair restoration protocols, often in combination with microneedling or low-level laser therapy.
5. I-PRF (Injectable PRF)
I-PRF is prepared without anticoagulants and via low-speed centrifugation, preserving white blood cells and fibrin.
Ideal for:
- Post-laser recovery
- Acne scar repair
- Deep dermal tissue regeneration
Its slow-release growth factor profile makes it ideal for long-term healing and remodeling.
6. A-PRF / C-PRF
Originally used in oral and maxillofacial surgery, these types contain a dense fibrin matrix and high concentrations of regenerative cells.
Used in:
- Deep facial injections
- Severe tissue aging
- Collagen matrix support and contouring
Though technically demanding, these are often applied in advanced anti-aging protocols and structural restoration therapies.
PRP Selection Based on Aesthetic Applications
Each type of PRP offers different mechanisms and outcomes. Matching the right PRP to the right procedure is key to achieving optimal results. Here’s how they compare across common beauty indications:
1. Facial Rejuvenation & Fine Line Reduction
Recommended: ACD-A PRP, HA PRP
Why: ACD-A is safe, stable, and works well with adjunct therapies; HA PRP adds hydration and mild volume enhancement for natural anti-aging effects.
2. Under-Eye Circles & Skin Brightening
Recommended: Sodium Citrate + Gel PRP
Why: Purified platelet layer improves microcirculation and skin tone, reducing pigmentation and puffiness.
3. Hydration and Dry Skin Management
Recommended: HA PRP
Why: Combines cellular repair and deep hydration, ideal for thin, dehydrated, or sensitive skin areas like crow’s feet and lips.
4. Hair Restoration & Scalp Revitalization
Recommended: Biotin PRP
Why: Biotin boosts follicular metabolism and enhances the efficacy of PRP in treating hair thinning and sebaceous imbalance.
5. Scar Remodeling & Post-Procedure Recovery
Recommended: I-PRF, C-PRF
Why: Long-acting release of growth factors enhances tissue repair and reduces inflammation, especially after invasive treatments or laser therapy.
Summary
- Define the Purpose – Determine if the goal is hydration, anti-aging, pigmentation correction, or hair restoration. Different PRP types target different issues.
- Assess Skin or Scalp Condition – For sensitive or healing skin, opt for fibrin-based formulations like I-PRF or C-PRF. For routine facial rejuvenation, classic ACD-A PRP suffices.
- Use in Combination Protocols – Choose PRP types compatible with other therapies. For instance, ACD-A or Gel-based PRP works well with fillers, microneedling, or RF devices.
PRP is not a one-size-fits-all solution. It’s a customizable regenerative tool. Knowing how to select and use it is the key to long-term success in aesthetic practice.
If you want to learn more about PRP or have any questions to consult us, please pay attention to our official websites: Sinymedical and Sinyprp.
FAQs
1. Is PRP treatment safe?
Yes. Since PRP is derived from the patient’s blood, it has no risk of immune rejection or cross-infection. It’s one of the safest injectable treatments available.
2. How soon can I see results after PRP treatment?
Initial results usually appear 7–10 days after treatment. Full effects are typically visible within 4 weeks. A series of 3 or more treatments is recommended for best results.
3. Can PRP be combined with other cosmetic procedures?
Absolutely. PRP can be used in conjunction with microneedling, laser treatments, fillers, or RF to enhance outcomes and accelerate healing.
4. Which PRP is best for fine lines around the eyes?
HA-enriched PRP is ideal, offering both regenerative stimulation and hydration for delicate skin.
5. Is I-PRF better than traditional PRP?
Not necessarily. I-PRF is excellent for healing and scar repair, but traditional PRP is better suited for standardized anti-aging and combination treatments.